review · ACS Applied Materials & Interfaces
Metal-organic frameworks are gaining recognition as artificial enzyme mimics, specifically serving as oxidase mimics. These materials provide notable advantages over traditional framework-based peroxidase systems and other nanomaterial oxidases, including higher catalytic activity, lower production costs, enhanced stability, and flexible structural design. Their primary utility lies in biochemical sensing applications. By systematically tailoring and modifying the underlying framework structures, researchers can optimise vital sensor performance metrics, particularly sensitivity, selectivity, and long-term stability. Clarifying the relationship between framework architectures and catalytic efficiency reveals the core mechanisms that make these materials effective nanozymes. Addressing the remaining operational challenges and functional opportunities supports the rational engineering of robust framework structures capable of powering diverse detection systems.
Natural enzymes can be delicate and expensive, which limits their practicality in routine testing. Metal-organic frameworks provide a resilient, lower-cost alternative by mimicking natural catalytic functions. Enhancing how these artificial enzymes are constructed allows for the creation of more dependable biochemical sensors, potentially improving monitoring tools used in healthcare, environmental screening, and industrial quality control.
The primary applications are biochemical sensors, which could serve developers of analytical equipment, diagnostic devices, and environmental monitoring tools. Because the evidence focuses on structural design strategies, performance optimisation, and unresolved technical challenges, the technology sits at an early stage of laboratory research and remains distant from market deployment.
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Metal-organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based oxidase systems. This review explores the various advantages that MOFs offer in terms of catalytic activity, low-cost, stability, and structural versatility. With a primary focus on their application in biochemical sensing, MOF-based oxidases have demonstrated remarkable utility, prompting a thorough exploration of their design and modification strategies. Moreover, the review aims to provide a comprehensive analysis of the strategies employed in the rational design and modification of MOF structures to optimize key parameters such as sensitivity, selectivity, and stability in the context of biochemical sensors. Through an exhaustive examination of recent research and developments, this article seeks to offer insights into the nuanced interplay between MOF structures and their catalytic performance, shedding light on the mechanisms that underpin their effectiveness as nanozyme mimics. Finally, this review addresses challenges and opportunities associated with MOF-based oxidase mimics, aiming to drive further advancements in MOF structure design and the development of highly effective biochemical sensors for diverse applications.
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DOI: 10.1021/acsami.4c17397
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