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article · Journal of Pharmaceutical Health Care and Sciences

Quillaja saponin mitigates methotrexate-provoked renal injury; insight into Nrf-2/Keap-1 pathway modulation with suppression of oxidative stress and inflammation

20245 citationsOpen accessBeni Suef University

Abstract

In conclusion, our results suggest the prophylactic and/or therapeutic effects of QBS in treating MTX-induced AKI. Such reno-protection is most-likely mediated via Nrf-2 induction that interferes with oxidant load, inflammatory pathways, and proapoptotic signaling.

Research topics

  • Chemotherapy-induced organ toxicity mitigation
  • Acute Lymphoblastic Leukemia research
  • Drug-Induced Hepatotoxicity and Protection

Sustainable Development Goals

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DOI: 10.1186/s40780-024-00330-4

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