article · RSC Advances

Pyrazolo[3,4- <i>d</i> ]pyrimidine derivatives as VEGFR-2 and EGFR <sup>T790M</sup> dual inhibitors: design, docking, ADMET, synthesis and anticancer evaluations

Nada A. A. M. Aziz
Riham F. George
Khaled El‐Adl
Tamer M. Nasr
Ghada F. Elmasry

20262 citationsOpen accessHeliopolis University

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Abstract

inhibition. Furthermore, molecules 7c, 7e and 8b exhibited excellent ADMET profile compared to sorafenib and erlotinib.

Research topics

HER2/EGFR in Cancer Research
Lung Cancer Treatments and Mutations
Colorectal Cancer Treatments and Studies

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DOI: 10.1039/d6ra00037a

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