article · The British Journal of Psychiatry

Psychiatric genetics research in Africa: challenges, opportunities and strategic insights from the Depression Genetics in Africa (DepGenAfrica) study

Jared G. Maina
Gerome Breen
Adeniran Okewole
Taiwo Lateef Sheikh
Mary Ramsay
Barkot Milkias
Amelia C. Crampin
N. Smyth
Solomon Teferra
James Walters
Andrew M. McIntosh

2026Open accessAhmadu Bello University

Abstract

The Depression Genetics in Africa (DepGenAfrica) study seeks to address the underrepresentation of African populations in psychiatric genomics by investigating the genetic basis of major depressive disorder in three African countries: Ethiopia, Malawi and Nigeria. This Editorial reflects on lessons from project set-up and offers recommendations, highlighting trust, communication, ethical oversight, data tools, workforce training and resource governance.

Research topics

Genetics, Bioinformatics, and Biomedical Research
BRCA gene mutations in cancer
Mental Health Treatment and Access

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DOI: 10.1192/bjp.2026.10578

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