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article · Frontiers in Cellular and Infection Microbiology

Proteomic signatures of COVID-19 Post-Vaccination/Post-Infection Syndrome (PV/PIS): insights into immune dysregulation and coagulopathy

Abstract

This proteomic signature was found to only partially overlap with that previously reported in a proteomics analysis on Long COVID samples, collected prior to vaccination availability. Our results highlight the complex interplay between immune activation, endothelial dysfunction, and coagulation pathologies in PV/PIS, with distinct differences detected between these systems in Long COVID and PV/PIS, paving the way for more targeted protein research in these conditions.

Research topics

  • SARS-CoV-2 and COVID-19 Research
  • Long-Term Effects of COVID-19
  • Peripheral Neuropathies and Disorders

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DOI: 10.3389/fcimb.2026.1753348

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