Proteinaceous Bacterial compounds isolated from different sources with multiple activities against cancer and microbial infection

Abstract

In recent years, global health authorities have had to deal with two significant problems : the alarming number of people suffering from cancer and the rise of antimicrobial resistance (AMR). Cancer is one of the major reasons for morbidity and mortality in the world while becoming a major concern of human health in the 21st century. In the year 2018, there were about 17.0 million new cases of cancer reported along with 9.5 million deaths worldwide due to cancer Tremendous efforts and progress have been made towards finding a cure for cancer. Another pandemic is hiding in plain sight. Antimicrobial resistance (AMR) is already a leading threat to global health and risks adversely affecting the environmental sustainability of the planet. The consequences of the continuing development and spread of AMR could be catastrophic AMR occurs when microbes such as bacteria, viruses, parasites and fungi are, or become, resistant to antimicrobial treatments to which they were previously susceptible. Antimicrobials are widely used in human and animal healthcare, and in crop and animal production Currently, bacterial proteins and peptides are important as antiproliferative agents. Some of these are already used in cancer treatment, others are in human clinical trials or studied in vitro. In this study glutaminase enzyme has been studied as anticancer and antimicrobial agent.