Protective Effect of Annona muricata Leaf Extract against Electrolytes Imbalance in Wistar Rats Induced with Acute Myocardial Infarction

Abstract

Annona muricata, a tropical fruit known for its medicinal properties, has been investigated for its potential cardioprotective effects, particularly in treating acute myocardial infarction (AMI), a critical condition caused by blocked coronary arteries. This study investigates protective effect of Annona muricata leaf extract against electrolytes imbalance in wistar rats induced with acute myocardial infarction. Thirty (30) wistar rats were randomly grouped into five classes (A, B, C, D and E) of six rats each. Groups A, B and C were pre-treated with 100mg/kg, 200mg/kg and 400mg/kg of Annona muricata extract respectively. Group D was administered 10 mg of lisinopril (standard drug), this served as the positive control group while group E was administered 0.2 mL distilled water, and this served as the negative control group. All the rats were intraperitoneally induced with 150 mg of isoproterenol after fourteen days (two weeks) of pretreatment. Serum electrolytes such as potassium and sodium were assayed using standard assay kit. Results showed that rats pre-treated with Annona muricata extract showed significant decrease (p>0.05) in the serum potassium and sodium levels in a dose dependent manner when compared to the untreated group; thereby suggesting that Annona muricata leaf extract may have a role in modulating sodium and potassium levels in animal models and may consequently help to mitigate the effect of cardiovascular disorders especially myocardial infarction.