PROGNOSTIC VALUE OF SERUM ADIPONECTIN LEVEL IN DIABETIC PATIENTS WITH AND WITHOUT HELICOBACTER PYLORI INFECTION

Abstract

Adipose tissue is a critical endocrine organ that secretes various adipocytokines, with adiponectin being the most abundant and essential for metabolic regulation. This hormone has anti-inflammatory and insulin-sensitizing effects, and its levels are inversely correlated with obesity and insulin resistance, positioning it as a potential prognostic marker for diabetes severity. Research suggests that Helicobacter pylori infection is linked to reduced adiponectin levels in diabetic patients, potentially worsening insulin resistance and increasing the risk of complications. Thus, monitoring serum adiponectin could help identify diabetic individuals at heightened risk for severe outcomes associated with HP co-infection.AIM:The aim of this study was to evaluate the association between serum adiponectin level and HP infection in diabetic patients with and without insulin resistance.METHODS: This study involved 100 participants divided into three groups: 40 diabetic patients with positive Helicobacter pylori (HP) infection, 30 diabetic patients without HP infection, and 30 matched healthy controls. Exclusion criteria included diabetic patients receiving insulin, those who smoked or were pregnant, and individuals with a history of HP treatment. Ethical considerations were made, ensuring data privacy and obtaining informed consent from all participants. Each participant underwent detailed clinical evaluations and laboratory investigations, which included blood tests for liver and renal function, inflammatory markers, and serum adiponectin levels, as well as assessments for HP infection and insulin resistance.