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review · International Journal of Endocrinology

Prevalence of Erectile Dysfunction in Patients with Diabetes Mellitus and Its Association with Body Mass Index and Glycated Hemoglobin in Africa: A Systematic Review and Meta-Analysis

202059 citationsOpen accessDebre Berhan University

In plain language

Erectile dysfunction represents a major complication for individuals living with diabetes mellitus, yet reported prevalence across African countries has historically varied. This systematic review and meta-analysis synthesised evidence from thirteen studies across Africa, covering 3,501 participants. The findings indicate an overall pooled erectile dysfunction prevalence of 71.45 percent among diabetic patients. The analysis also examined associations with body mass index and glycated haemoglobin levels. Diabetic patients with a body mass index of 30 or greater were found to be 1.26 times more likely to have erectile dysfunction, while those with glycated haemoglobin below seven percent were seven percent less likely to experience it. However, neither of these associations was statistically significant. The high overall burden highlights the necessity for situation-based clinical interventions and country-specific preventive strategies tailored to diabetic populations across the African continent.

Key takeaways

  • The pooled prevalence of erectile dysfunction among patients with diabetes mellitus in Africa was estimated at 71.45 percent.
  • Patients with a body mass index of 30 or higher were 1.26 times more likely to present with erectile dysfunction, though the link was not statistically significant.
  • Patients with glycated haemoglobin below seven percent were seven percent less likely to develop erectile dysfunction, but this association also lacked statistical significance.
  • Evidence drawn from thirteen studies and 3,501 participants points to a high burden requiring context-specific preventive healthcare strategies.

Why it matters

Diabetes complications severely affect quality of life, yet sexual health issues such as erectile dysfunction are frequently under-addressed. By establishing that over seventy percent of diabetic men in Africa may experience erectile dysfunction, this analysis provides healthcare planners and clinicians with vital baseline data. It underscores the urgency of integrating sexual health assessments and targeted preventive measures into routine diabetes management programmes across the region.

Commercialisation angle

The abstract does not indicate a direct commercial application pathway, as it focuses strictly on epidemiological prevalence and risk factors to inform preventive health strategies.

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Abstract

Background . Mortality and morbidity in patients with diabetes mellitus (DM) are attributed to both microvascular and macrovascular complications. However, there is a significant amount of variation in the primary studies on DM regarding the prevalence of erectile dysfunction (ED) in Africa. Therefore, this study was aimed to estimate the pooled prevalence of ED patients with DM and its association with body mass index (BMI) and glycated hemoglobin in Africa. Methods . PubMed, Web of Science, Cochrane Library, Scopus, PsycINFO, African Journals Online, and Google Scholar were searched for studies that looked at ED in DM patients. A funnel plot and Egger’s regression test were used to determine publication bias. The I 2 statistic was used to check heterogeneity between the studies. DerSimonian and Laird random-effects model was applied to estimate the pooled effect size. The subgroup and meta-regression analyses were conducted by country, sample size, and year of publication. Sensitivity analysis was deployed to see the effect of a single study on the overall estimation. STATA version 14 statistical software was used for the meta-analysis. Result . A total of 13 studies with 3,501 study participants were included in this study. We estimated that the pooled prevalence of ED in patients with DM in Africa was 71.45% (95% CI: 60.22–82.69). Diabetic patients whose BMI was ≥30 kg/m 2 were 1.26 times more likely to develop ED (AOR = 1.26; 95% CI: 0.73–2.16) and whose glycated hemoglobin was <7% were 7% less likely to develop ED (AOR = 0.93; 95% CI: 0.5–5.9), although they were not significantly associated with ED. Conclusions . The prevalence of ED in DM patients in Africa remains high. Therefore, situation-based interventions and country context-specific preventive strategies should be developed to reduce the prevalence of ED among patients with DM.

Research topics

  • Sexual function and dysfunction studies
  • Hormonal and reproductive studies
  • Urinary Bladder and Prostate Research

Sustainable Development Goals

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DOI: 10.1155/2020/5148370

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