review · BMC Endocrine Disorders
This systematic review and meta-analysis aimed to estimate the overall prevalence of diabetic peripheral neuropathy (DPN) among diabetes mellitus patients in Africa. Researchers systematically searched various online databases, adhering to PRISMA guidelines, and employed a random-effect model for prevalence estimation. The analysis incorporated 23 studies, encompassing 269,691 participants. The findings revealed a high overall pooled prevalence of DPN at 46%. Subgroup analysis indicated that West Africa recorded the highest prevalence at 49.4%. The study concludes that DPN is relatively common in Africa, underscoring the necessity for situation-based interventions and preventive strategies specific to each country.
Diabetic peripheral neuropathy can lead to serious complications such as ulcers and amputations, imposing significant health and economic burdens. Recognising its high prevalence in Africa is vital for developing targeted public health programmes and interventions to reduce disability and improve patient outcomes across the continent.
This research highlights a substantial health challenge in Africa, indicating a clear need for new or improved interventions and preventive strategies for diabetic peripheral neuropathy. While the abstract does not specify particular products or services, it suggests a market for diagnostic tools, treatment options, and public health programmes tailored to African contexts. This is early-stage research identifying a problem that requires solutions.
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Abstract Background Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amount of variation in the primary studies on DM regarding the prevalence of DPN in Africa. Hence, this study was aimed to estimate the overall prevalence of DPN in DM patients in Africa. Methods PubMed, Scopus, Google Scholar, African Journals OnLine, WHO African Library, and the Cochrane Review were systematically searched online to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines was followed. Heterogeneity across the included studies was evaluated by the inconsistency index (I 2 ). Publication bias was examined by funnel plot and Egger’s regression test. The random-effect model was fitted to estimate the pooled prevalence of diabetic peripheral neuropathy among patients in Africa. The meta-analysis was performed using the STATA™ Version 14 software. Results Twenty-three studies which includes 269,691 participants were included in the meta-analysis. The overall pooled prevalence of diabetic peripheral neuropathy was 46% (95% CI:36.21–55.78%). Based on the subgroup analysis, the highest prevalence of diabetic peripheral neuropathy in DM patients was reported in West Africa at 49.4% (95% CI: 32.74, 66.06). Conclusion This study revealed that the overall prevalence of diabetic peripheral neuropathy is relatively high in Africa. Hence, DPN needs situation-based interventions and preventive strategies, which are specific to the country. Further meta-analysis is needed to identify associated factors for the occurrence of diabetic peripheral neuropathy.
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DOI: 10.1186/s12902-020-0534-5
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