article · International Journal of Microbiology
Urinary tract infections present a substantial health burden, yet data regarding the specific bacterial pathogens and their resistance profiles in diabetic patients remain limited in Ethiopia. A comparative study of 384 hospital patients examined urine samples to identify bacterial strains and evaluate their resistance to common antimicrobials. Bacteria were isolated from 10.9 percent of diabetic patients compared to 4.7 percent of non-diabetic individuals. Gram-positive bacteria represented the majority of isolates at 58.1 percent, with gram-negative species accounting for 41.9 percent. Furthermore, 58.8 percent of the gram-positive isolates showed resistance to cotrimoxazole. Overall, multidrug resistance against two or more antibiotics occurred in 56.7 percent of all identified bacterial isolates. The presence of bacteriuria demonstrated statistically significant links to patient sex and the specific type of diabetes, underscoring the urgent requirement for rational antimicrobial prescribing practices.
Diabetic individuals face an elevated risk of bacterial infections that can lead to severe health complications. High rates of resistance to commonly prescribed antibiotics complicate standard treatment protocols. Providing local susceptibility data helps healthcare providers choose effective treatments, improving patient recovery and helping to contain the spread of multidrug-resistant bacteria within hospital settings and broader communities.
The abstract does not indicate a direct commercialisation pathway or product development plan. The findings represent early-stage observational clinical research that provides surveillance data. While this information could inform clinical guidelines or guide local diagnostic laboratories and pharmaceutical distributors on drug efficacy, no specific commercial application, technology, or industrial partnership is described.
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Background . Urinary tract infection is a major health problem especially in developing countries. Information about bacterial pathogens isolated from urinary tract infection in diabetic patients and their antimicrobial susceptibility patterns is limited in Ethiopia. Therefore, this study aimed at isolating bacterial pathogens and their antimicrobial susceptibility patterns. Methods . A hospital based comparative cross-sectional study was conducted at Debre Tabor. Urine sample was inoculated onto cysteine lysine electrolyte deficient (CLED) medium. Bacterial pathogens were identified using standard bacteriological methods. The data were cleaned and entered into SPSS version 20.<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>P</mml:mi></mml:mrow></mml:math>value less than 0.05 is considered statistically significant. Result . A total of 384 study participants were included in the study. Of them, 21 (10.9%) were from diabetics and 9 (4.7%) of them were from nondiabetics. Large proportion of gram positive bacteria at 18 (58.1%) were isolated compared to gram negatives at 13 (41.9%). Gram positive isolates were resistant to cotrimoxazole 10 (58.8%). Conclusion . The isolation rates of bacterial pathogens were higher in diabetic than nondiabetic patients. Bacteriuria was significantly associated with sex and type of diabetes. Multidrug resistance to two or more antibiotics was observed in 56.7% of bacterial isolates. Rational use of antimicrobial agent should be thought of to prevent the emergence of multidrug resistance.
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DOI: 10.1155/2017/5809494
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