Preparation and in-vitro evaluation of dyphylline controlled release matrix tablets

Abstract

The aim of this study was to create controlled release matrix tablets of Dyphylline, a xanthine derivative used for the management of various respiratory conditions such as asthma, cardiac dyspnea, chronic bronchitis, and emphysema. The researchers employed a direct compression method and various polymers to achieve this. The resulting matrix tablets were evaluated through infrared spectral analysis, differential thermal analysis, and evaluations of hardness, friability, content uniformity, and in-vitro drug release. The release profiles were also analyzed through different kinetic orders. The results showed that all Dyphylline formulae followed Higuchi's diffusion model, indicating that diffusion is the mechanism of drug release from the controlled matrix tablets. The infrared and differential thermal analyses demonstrated that there was no incompatibility between Dyphylline, and the polymers used in the formulations. The study concluded that the direct compression method is an effective approach for the formulation of hydrophilic Dyphylline and that a high polymer content leads to a longer T1/2 and decreased drug release due to improved retention.