Predictors of obesity in hypothyroid patients under treatment

Abstract

Objectives: to evaluate obesity and insulin resistance relation in treated hypothyroid patients attending Menoufia university hospital. Background: Hypothyroidism is a common endocrine disorder resulting from deficient secretion of thyroid hormone. Africa has the highest prevalence (14.2%) while Asia has the lowest prevalence (5.8%). “obesity” is a disease where body fat and body-fat distribution exceed the level considered healthy. Through the production of adipokines adipose tissue affects the activity of the Hypothalamic–pituitary–thyroid (HPT) axis system. Insulin resistance and autoimmune thyroid disease have shown to influence each other. Patient and methods: Our study included 254 Egyptian hypothyroid patients under treatment divided into 2 groups group A (hypothyroid obese) and group B (hypothyroid non-obese) to study Obesity predictors in treated Hypothyroid Patients Attending Menoufia University Hospital. They were assessed for systolic blood pressure (SBP), diastolic blood pressure (DBP), Body mass index (BMI) and investigated for Serum levels of thyroid-stimulating hormone (TSH), serum levels of free triiodothyronine (FT3), free thyroxine (FT4), fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), Thyroid peroxidase (Anti-TPO) antibody, fasting serum lipid profile and total leucocytic counts (neutrophils and lymphocytes). The Results: HOMA-IR, SBP, TGs, DBP, and FT4 were ranked in descending order by odd ratio as independent predictors of obesity, with the exception of FT3, FBG, TC, and LDL-C. Conclusion: Targeting multiple factors as (Insulin Resistance, good control of blood pressure, treatment of hypertriglyceridemia and control of low FT4) is a priority to lose weight and get rid of obesity in hypothyroid patients.