Preclinical Evidence of Curcuma longa Linn. as a Functional Food in the Management of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Rodent Studies

Abstract

<b>Background/Objectives</b>: Metabolic syndrome (MetS) is a multifactorial condition characterized by abdominal obesity, dyslipidemia, insulin resistance, hypertension, and chronic inflammation. As its global prevalence rises, there is increasing interest in natural, multi-targeted approaches to manage MetS. <i>Curcuma longa</i> Linn. (turmeric), especially its active compound curcumin, has shown therapeutic promise in preclinical studies. This systematic review and meta-analysis evaluated the effects of <i>Curcuma longa</i> and its derivatives on MetS-related outcomes in rodent models. <b>Methods</b>: A comprehensive search was conducted across six databases (PubMed, Scopus, AMED, LILACS, MDPI, and Google Scholar), yielding 47 eligible in vivo studies. Data were extracted on key metabolic, inflammatory, and oxidative stress markers and analyzed using random-effects models. Results were presented as mean differences (MD) with 95% confidence intervals (CI). <b>Results</b>: Meta-analysis showed that curcumin significantly reduced body weight (rats: MD = -42.10; mice: MD = -2.91), blood glucose (rats: MD = -55.59; mice: MD = -28.69), triglycerides (rats: MD = -70.17; mice: MD = -24.57), total cholesterol (rats: MD = -35.77; mice: MD = -52.61), and LDL cholesterol (rats: MD = -69.34; mice: MD = -42.93). HDL cholesterol increased significantly in rats but not in mice. Inflammatory cytokines were markedly reduced, while oxidative stress improved via decreased malondialdehyde (MDA) and elevated superoxide dismutase (SOD) and catalase (CAT) levels. Heterogeneity was moderate to high, primarily due to variations in curcumin dosage (ranging from 10 to 500 mg/kg) and treatment duration (2 to 16 weeks) across studies. <b>Conclusions</b>: This preclinical evidence supports <i>Curcuma longa</i> as a promising functional food component for preventing and managing MetS. Its multi-faceted effects warrant further clinical studies to validate its translational potential.