MARATTO

article · Current Pharmaceutical Design

Precision Design in Cancer Treatment: Cucurbitacin E Modulates AMPK, PGK1, and PKM2 to Optimize Radiation Efficacy in Melanoma

Abstract

CE acts as a potent radiosensitizer, augmenting γ-irradiation-induced apoptosis in A375 cells through metabolic disruption, oxidative stress modulation, intrinsic apoptotic activation, and cell cycle arrest. These results highlight its potential for improving melanoma radiotherapy. Future research should optimize dosing regimens and explore clinical translation to advance precision oncology strategies.

Research topics

  • Advances in Cucurbitaceae Research
  • Curcumin's Biomedical Applications
  • Toxin Mechanisms and Immunotoxins

Sustainable Development Goals

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

DOI: 10.2174/0113816128418138251206141825

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.