Potential Effect of Apricot Kernel Powder on Hepatocarcinomic rats Induced by Potassium Bromate التأثير المحتمل لمسحوق نوي المشمش علي الفئران المصابه بسرطان الكبد المستحث بواسطه برومات البوتاسيوم

Abstract

Apricot kernels are rich in protein and fat, and many anti-cancer compounds. The current study was designed to examine the potential impact of apricot kernel powder (AKP) on rats with cancerous livers induced by potassium bromate. Thirty adult male albino rats, with an average weight of 150±10 g, were divided randomly into two main groups. Group 1 was given a standard diet and served as the negative control group (normal rats). Group 2 was administered a single intraperitoneal dose of potassium bromate at 125 mg/kg body weight to induce oxidative stress and follicular cells, then divided into 4 subgroups. Group 2 remained as the positive control group and received only the standard diet, while groups 3, 4, and 5 were given AKP at concentrations of 10%, 20%, and 30%, respectively. Throughout the 28-day experimental period, each rat's weight was monitored individually, and at the end of the study period, the rats were euthanized, and blood samples were collected. Biological and biochemical parameters were evaluated, and the potential cytotoxic activity against liver carcinoma cell line was measured. The outcomes demonstrated inhibition and repression at consume of AKP at some tumor parameter, as Interferons alpha (IFN-alpha), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), Protein carbonyl oxidation (PCO), Alpha-fetoprotein (AFP) and improving at oxidative parameters and liver function and lipid profiles. The best results were for groups fed with 30% of AKP.