article · The Journal of Infectious Diseases

Postmortem Analysis of Dolutegravir, Tenofovir, Lamivudine, and Efavirenz Penetration in Multiple Central Nervous System Compartments

Fan Wang
Olivie C. Namuju
James Fisher
Robert Lukande
David R. Boulware
Kizito Abdusalaamu
David B. Meya
MaryPeace McRae
Kara M. Rademeyer
Melanie R. Nicol

20243 citationsOpen accessMakerere University

Abstract

Analysis of postmortem tissue provides a unique opportunity to investigate CNS antiretroviral penetration. Regional differences were observed paving the way to identify mechanisms of viral compartmentalization and/or neurotoxicity.

Research topics

HIV Research and Treatment
Infectious Encephalopathies and Encephalitis
HIV/AIDS Research and Interventions

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1093/infdis/jiae325

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