review · Cancers
Colorectal cancer remains a major healthcare challenge that demands novel therapeutic strategies. Natural polyphenols demonstrate inherent anticancer properties, making them attractive candidates for therapy. Formulating polyphenol-based nanoparticles can significantly enhance these natural characteristics. Several synthesis routes exist to produce these nanomaterials, including polymerisation, chemical conjugation, dynamic covalent bonding, non-covalent bonding, reduction, and metal-polyphenol networks. Once formulated, these nanoparticles operate through both active and passive targeting mechanisms to reach cancer sites. A diverse range of delivery platforms can carry polyphenols, including liposomes, micelles, nanogels, nanoemulsions, gold nanoparticles, mesoporous silica nanoparticles, and metal-organic frameworks. While these delivery approaches show strong therapeutic promise for colorectal cancer, further research remains necessary to optimise their overall efficacy and safety profiles.
Colorectal cancer is difficult to treat effectively using conventional interventions alone. Natural polyphenols show strong anticancer effects, but delivering them effectively remains a challenge. Using nanoparticles to package and transport these natural compounds enables more precise tumour targeting, offering a foundation for therapies that may improve cancer treatment outcomes while limiting harm to healthy tissue.
The described technologies apply to advanced drug delivery systems for oncology therapeutics, primarily of interest to pharmaceutical developers and formulation chemists. Because the findings outline various carrier platforms and emphasise the need for further optimisation of safety and efficacy, the research is at an early stage. Extensive laboratory formulation work and clinical testing will be required before these systems can reach market readiness.
AI-generated from the published abstract. Always read the original work before citing.
Colorectal cancer (CRC) poses a significant challenge in healthcare, necessitating the exploration of novel therapeutic strategies. Natural compounds such as polyphenols with inherent anticancer properties have gained attention as potential therapeutic agents. This review highlights the need for novel therapeutic approaches in CRC, followed by a discussion on the synthesis of polyphenols-based nanoparticles. Various synthesis techniques, including dynamic covalent bonding, non-covalent bonding, polymerization, chemical conjugation, reduction, and metal-polyphenol networks, are explored. The mechanisms of action of these nanoparticles, encompassing passive and active targeting mechanisms, are also discussed. The review further examines the intrinsic anticancer activity of polyphenols and their enhancement through nano-based delivery systems. This section explores the natural anticancer properties of polyphenols and investigates different nano-based delivery systems, such as micelles, nanogels, liposomes, nanoemulsions, gold nanoparticles, mesoporous silica nanoparticles, and metal-organic frameworks. The review concludes by emphasizing the potential of nanoparticle-based strategies utilizing polyphenols for CRC treatment and highlights the need for future research to optimize their efficacy and safety. Overall, this review provides valuable insights into the synthesis, mechanisms of action, intrinsic anticancer activity, and enhancement of polyphenols-based nanoparticles for CRC treatment.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.3390/cancers15153826
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
