article · Discover Food
Pogostone is a natural secondary metabolite derived from the plant Pogostemon cablin that demonstrates diverse biological properties in cellular and animal models. Documented effects include antioxidant, anti-inflammatory, antimicrobial, and gastroprotective activities. These outcomes stem from the modulation of vital molecular signalling pathways related to oxidative stress and inflammation, including Nrf2, NF-κB, MAPK, SIRT1, and the NLRP3 inflammasome. Through these actions, pogostone helps regulate redox balance, protect the intestinal barrier, and control microbial growth. Emerging research also outlines its biosynthetic routes and its metabolic transformation within mammalian systems, offering preliminary insights into its behaviour following oral consumption. Although pogostone shows strong potential as a plant-derived bioactive ingredient for functional foods and nutraceuticals targeting gastrointestinal and metabolic health, further interdisciplinary research remains necessary before practical uses can be realised.
Dietary components that actively reduce inflammation and protect the digestive tract are increasingly central to preventative health. Understanding how pogostone works at a molecular level highlights how natural plant substances can defend against oxidative damage, suppress inflammatory responses, and control harmful microbes. This provides a scientific foundation for creating healthier diets and targeted nutritional interventions.
The compound is targeted at product developers in the functional food, nutraceutical, and food preservation sectors. It could enable new formulations that support metabolic and gastrointestinal wellbeing or natural shelf-life extension. However, this technology sits at an early research stage, having been tested primarily in cellular and animal models, and requires further interdisciplinary investigation before commercial product formulation or market entry can occur.
AI-generated from the published abstract. Always read the original work before citing.
Pogostone, a characteristic secondary metabolite of Pogostemon cablin , has recently gained attention due to its diverse biological activities and potential relevance as a bioactive compound for functional food development. This review summarizes current knowledge on the origin, biosynthesis, biological activities, molecular mechanisms, and potential applications of pogostone, with particular emphasis on properties relevant to food and nutrition science. Available studies demonstrate that pogostone exhibits notable antioxidant, anti-inflammatory, antimicrobial, and gastroprotective activities in both cellular and animal models. These effects are associated with the modulation of key signaling pathways involved in oxidative stress and inflammation, including Nrf2, NF-κB, MAPK, SIRT1, and the NLRP3 inflammasome. Such mechanisms suggest that pogostone may contribute to the regulation of redox balance, intestinal barrier protection, and microbial control processes that are closely linked to the development of functional foods aimed at supporting gastrointestinal and metabolic health. In addition to its biological effects, emerging research has explored the biosynthetic pathways of pogostone and its metabolic transformation in mammalian systems, providing initial insights into its pharmacokinetic behavior after oral exposure. Pogostone represents a promising plant-derived bioactive compound with potential relevance for nutraceutical and functional food innovation, although further interdisciplinary research is required to support its practical applications.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1007/s44187-026-01209-z
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
