Platelet/Lymphocyte Ratio (PLR) as Prognostic Factor Thrombocytopenic Purpura in Patients of Immune

Abstract

Abstract Background platelet/lymphocyte ratio (PLR) is a new inflammatory marker and its level increases in many inflammatory diseases, diabetes and malignancy. In ITP patients thereis decrease in platelet count beside inflammation, so PLR is a good prognostic factor in ITP. Objective The aim of the study is to know the relation between platelet /lymphocytes ratio and the prognosis of immune thrombocytopenia Patients and Methods This was prospective study conducted on 96 patients diagnosed as immune thrombocytopenic purpura attending hematology unit of Ain Shams University divided into to3 groups (newly diagnosied, Resistant and splenectomized) and followed them after 3 months. Results Comparison between ITP sub-groups regarding CBC results at baseline revealed that Newly diagnosed ITP patients had significantly higher PLR compared to other groups while resistant/relapsed ITP patients had significantly lower PLR compared to other two groups. (table 2). Comparison between ITP sub-groups regarding CBC results after 3 months revealed that resistant/relapsed ITP patients had significantly lower PLR compared to other two groups, (table 3). on comparison PLR in newly-diagnosed ITP before and after 3 months of treatment PLR was higher Highly significant (P < 0.001) On comparison PLR in Resistant group pre and after 3 months of treatment it was lower highly significant (p < 0.001) On comparison PLR in splenectomy group pre and after 3 months of treatment PLR was higher Highly significant (p < 0.001) Conclusion PLR is a good indicator for ITP patient of different categories (newly diagnosied, Resistant and splenectomized).