PLASMA KINETIC PARAMETERS OF MEDICINAL SYNTHETIC ALUMINIUM MAGNESIUM SILICATE IN BROILERS

Abstract

Despite the volume of research on the medical relevance of medicinal synthetic aluminium magnesium silicate (MSAMS), there is no documented evidence regarding its absorption, distribution, metabolism or excretion in either humans or animals. To provide experimental evidence that MSAMS is absorbable, thus, can be used to treat systemic infections, thirty eighty (38) broilers which were raised from day old till they were six weeks old were drenched a single dose of 50 mg/kg MSAMS orally. Blood was collected from each chick post treatment (PT) at: 0.25, 0.5, 1, 2, 3, 6, 9, 12, 24, 36 and 48 hours, for evaluation of plasma-MSAMS concentrations. Means of plasma MSAMS concentrations in the broilers varied significantly (P≤ 0.05) between each time interval from 0 h (before drug administration: 0.51 ± 0.12) through time 0.25 h PT (0.97 ± 0.13) to 48 h PT (1.23 ± 0.15) with maximum concentration (Cmax: 1.87 ± 0.14) recorded at 0.5 h PT. The pharmacokinetic parameters recorded were Tmax (0.5h), AUC₀–t (59.72 ± 5.23), AUC₀–∞ (195.68 ± 28.4), T1/2α (h) (0.201 ± 0.024), β (1/h) (0.0090 ± 0.0012), T1/2β (h) (76.68 ± 12.3) and Vd (28.3 ± 4.6). The results showed that the MSAMS is absorbable.