article · Malaria Journal

Plasma folate dynamics in Plasmodium falciparum-infected African children treated with artemisinin combination therapy and single low-dose primaquine or placebo

Solomon Damilare Ajayi
Thomas N. Williams
Caterina Fanello
Nicholas Day
Kathryn Maitland
Chiraporn Taya
Marie Onyamboko
Sophie Uyoga
Natenapa Chimjinda
Mavuto Mukaka
Dhol S Ayuen
Peter Olupot‐Olupot
Walter Taylor

2025Open accessUniversité de Kinshasa (UNIKIN)

Abstract

SLDPQ and G6PD status did not compromise posttreatment plasma folate concentrations in young children with acute uncomplicated falciparum malaria, providing additional evidence of SLDPQ safety and supporting its use without G6PD testing. Trial registration The trial is registered, reference number ISRCTN11594437.

Research topics

Pharmacological Effects and Toxicity Studies
HIV/AIDS drug development and treatment
Hemoglobinopathies and Related Disorders

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DOI: 10.1186/s12936-025-05567-4

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