article · Cosmetics
Moroccan Henna (Lawsonia inermis) leaves collected from three southeastern locations, Alnif, Tafraoute Sidi Ali and Tazarine, were analysed to evaluate their healing properties for cosmetic and therapeutic formulations. Phytochemical testing revealed that Henna from Alnif contained the highest levels of phenolic compounds, flavonoids, tannins and the colouring agent Lawsone, whereas the Tazarine extract contained the highest amount of saponins. Specific topical formulations incorporating a 10% dose of aqueous Henna extract into petroleum jelly were tested on induced burns in Swiss albino mice. Over a 21-day period, formulations from all three locations accelerated wound contraction and achieved complete re-epithelialisation compared to controls of petroleum jelly alone and petroleum jelly with 1% flamazine. These results highlight the potential of Henna extracts as bioactive ingredients for skin repair.
Burn wounds require effective treatments that promote tissue repair and prevent complications. Demonstrating that Henna extracts rich in phenolic compounds accelerate skin re-epithelialisation in animal models highlights a plant-derived alternative for skin recovery. This offers scientific evidence that traditional botanical resources can contribute to modern burn care and skin health.
This research could enable the development of topical dermatological and cosmetic treatments for wound and burn healing. Manufacturers of skincare products, burn care therapies and botanical formulations could utilise these findings. Because the work is currently applied and tested only in Swiss albino mice, further development and clinical trials will be necessary before commercial human use.
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The present study aims at valorizing Moroccan Henna (Lawsonia inermis) by developing healing formulations for cosmetic and therapeutic uses. For such a goal, the plant was collected from three locations in southeastern Morocco (Alnif, Tafraoute Sidi Ali and Tazarine). Phytochemical analysis of Henna leaves was performed by determining phenolic compound contents, and flavonoids and tannins in it, through its aqueous extracts. Then, specific formulations were prepared using aqueous extracts of L. inermis to assess their in vivo wound healing potential in Swiss albino mice used as animal models. Results disclosed that phenolic compounds (13.48%), as well as flavonoid (9.25%) and tannin (2.57%) contents are higher in Henna leaf extracts from Alnif, while Tazarine Henna aqueous extract was found to be richer in saponins (0.32%). Exclusion chromatographic analysis on Sephadex G50 gel corroborates the obtained results and shows that Lawsone levels (Henna coloring agent) are higher in Henna collected from Alnif. Aqueous Henna leaf extracts, at a dose of 10% in petroleum jelly, have been assessed for their ability to heal induced burns in mice. Healing monitoring, carried-out with Henna extracts on mice batches and those of two control batches (mice batch treated with petroleum jelly alone and batch treated with petroleum jelly containing 1% (flamazine), showed a great reduction in burnt surface with an accentuated contraction percentage (CP) and complete re-epithelialization duration (CRD) at 21 days in the 3 studied Henna-based formulations. These findings suggest the interest of potential development of Henna-based formulations, as a source of phenolic compounds, for further dermatological, cosmetic and therapeutic applications.
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DOI: 10.3390/cosmetics10030092
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