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article · Frontiers in Oncology

Patterns of expression of VEGFR2, PDGFRs and c-Kit in pediatric patients with high grade non-rhabdomyosarcoma soft tissue sarcoma

20242 citationsOpen accessBeni Suef University

Abstract

Our findings indicated that tyrosine kinase receptors are upregulated in NRSTS and exhibited a distinct expression pattern within various subgroups. High expression of VEGFR2 and PDGFRα significantly correlated with reduced survival and may guide targeted therapy approaches for this poor prognosis group of patients.

Research topics

  • Sarcoma Diagnosis and Treatment
  • Vascular Tumors and Angiosarcomas
  • Angiogenesis and VEGF in Cancer

Sustainable Development Goals

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DOI: 10.3389/fonc.2024.1480773

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