Pathological Assessment of Aspirin-Induced Gastric Ulcers Treated with Cordia Myxa

Abstract

This study investigates the therapeutic potential of Cordia myxa extract in treating gastric ulcers induced by Aspirin in rats, motivated by the limitations of existing treatments and the growing interest in herbal remedies, which are often associated with better cultural acceptance and fewer side effects.Forty-eight male albino rats were divided into six groups of eight. The control group received saline via gastric gavage, while the remaining groups were administered 500 mg/kg body weight of Aspirin once orally to induce gastric ulcers. The early ulcer group was sacrificed 6 hours post-Aspirin administration, while the late ulcer group was sacrificed 14 days later. The ulcer & Cordia myxa group received the extract at a dosage of 125 mg/kg/day for 14 days following Aspirin treatment. The ulcer & Pantoprazole group was treated with Pantoprazole at 40 mg/kg/day for the same duration, and the ulcer, Cordia myxa & Pantoprazole group received both treatments at the same dosages for 14 days after Aspirin induction.Histopathological analysis revealed severe gastric damage and bleeding in both the early and late ulcer groups, indicated by a significantly elevated ulcer index. In contrast, the group receiving both Cordia myxa and Pantoprazole demonstrated significantly reduced ulceration, well-preserved gastric mucosa, and intact epithelium, with a notable decrease in the ulcer index and high inhibition index compared to the late ulcer group. These results suggest that the combination of Cordia myxa and Pantoprazole provides an effective treatment for gastric ulcers, as confirmed by both macroscopic and histological evaluations.