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article · Frontiers in Aging Neuroscience

Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats

2026Open accessMansoura University

Abstract

The results suggest that oxytocin modulates stress responses, oxidative balance, and inflammatory pathways in aged rats subjected to chronic sleep deprivation. Although the precise central mechanisms remain unresolved, these findings support a potential role for oxytocin in mitigating SD-associated pathophysiological changes in aging and warrant further mechanistic studies to clarify its neuroprotective potential.

Research topics

  • Neuroendocrine regulation and behavior
  • Sleep and Wakefulness Research
  • Circadian rhythm and melatonin

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DOI: 10.3389/fnagi.2026.1742343

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