article · medRxiv
Understanding host susceptibility to <i>Mycobacterium tuberculosis</i> ( <i>Mtb)</i> is critical for the development of new vaccines. Certain individuals "resist" becoming infected with <i>Mtb</i> despite intensive exposure; however, it is unknown whether there is a genetic basis for "resistance" to <i>Mtb</i> infection across populations. Here we conducted a genome-wide association study (GWAS) of resistance to <i>Mtb</i> infection by carefully characterizing exposure to TB patients among 4,058 close contacts in India, Brazil, and South Africa. 476 (12%) "resisters" remained free of <i>Mtb</i> infection despite substantial exposure to highly infectious TB patients. GWAS identified a novel chromosome 13 locus (rs1295104126) associated with resistance across the multi-ancestry meta-analysis. Comparing <i>Mtb</i> -infection to all uninfected contacts, irrespective of exposure, yielded a different locus on chromosome 6 (rs28752534), near the HLA-II region. These findings demonstrate a common genetic basis for resistance to <i>Mtb</i> infection across multi-ancestral cohorts with potential to elucidate novel mechanisms of protection from <i>Mtb</i> infection.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.64898/2026.03.06.26347614
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
