article · Future Medicinal Chemistry
<b>Aim:</b> The indandione nucleus, is one of the most amazing nuclei in medicinal chemistry, is used to design new derivatives.<b>Methods & materials:</b> Novel indandione derivatives are prepared with different electrophilic and nucleophilic reagents to yield <b>3</b>, <b>4</b>, <b>8</b>, <b>11</b>, <b>14</b>, <b>16, 19, 20, 21, 22</b> and <b>23</b>. Compounds <b>8, 11, 16, 20</b> and <b>23</b> are investigated against OVCAR-3 and HeLa, using LLC-MK2 and <i>cis</i>-Pt as references. <i>in silico</i> and spectral studies were analyzed for the selected compounds.<b>Results:</b> Compounds <b>20</b> and <b>23</b> at 100 ns were the most potent compounds, so molecular dynamics studies were performed.<b>Conclusion:</b> Compound <b>23</b> was the most active toward the HeLa cervical cell line, and compound <b>20</b> was the most active toward the Ovcar-3 cell line.
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DOI: 10.1080/17568919.2024.2351350
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