article · Frontiers in Pharmacology

Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress

Nevertyty M. Mahmoud
Tahani Saeedi
Sheka Yagub Aloyouni
Manal S. Fawzy
Afaf Aldahish
S. Abed
Gehan A. Ahmed
Fatma El-shaarawy
Sawsan A. Zaitone
Shimaa M. Elshazly
Shaimaa S. El-Sayed

20242 citationsOpen accessSuez Canal University

In plain language

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Abstract

NTZ exerted a hepatoprotective effect in MTX-challenged rats that is mediated via modulation of ER stress and inhibiting apoptosis.

Research topics

Endoplasmic Reticulum Stress and Disease
Liver Disease Diagnosis and Treatment
Liver Disease and Transplantation

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.3389/fphar.2024.1491249

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