article · Clinical Infectious Diseases

New Manual Quantitative Polymerase Chain Reaction Assay Validated on Tongue Swabs Collected and Processed in Uganda Shows Sensitivity That Rivals Sputum-based Molecular Tuberculosis Diagnostics

Amy Steadman
Alfred Andama
Job Mukwatamundu
John Connelly
Patrick Phillips
Tessa Mochizuki
Catherine Cook
William Worodria
Christine Bachman
David Katumba
Annet Nakaweesa
J Kato
Alexey Ball
Talemwa Nalugwa
Lucy Asege
Sandra Mwebe
Martha Nakaye
Bernhard H. Weigl
Fred C. Semitala
Esther Kisakye
Wilson Mangeni
Irene Nassuna
Justine Nyawere
Khushboo Khimani
Alice Bukirwa
Adithya Cattamanchi

202442 citationsOpen accessMakerere University

Abstract

Tongue swabs are a promising alternative to sputum for molecular diagnosis of TB, with sensitivity approaching sputum-based molecular tests. Our results provide valuable insights for developing successful tongue swab-based TB diagnostics.

Research topics

Mycobacterium research and diagnosis
Infectious Diseases and Tuberculosis
Tuberculosis Research and Epidemiology

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1093/cid/ciae041

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