New Hybrid Pyrazole–Imidazole Compounds: Synthesis, Characterization, and Evaluation of Their α‐Amylase Inhibition Activity

Abstract

Abstract The synthesis of a new family of pyrazole–imidazole hybrid compounds 3a – 3f is reported. These compounds were obtained in one step through an equimolar condensation of pyrazole and imidazole derivatives. The corresponding structures were confirmed by 1 H and 13 C NMR spectroscopy, as well as high‐resolution mass spectrometry (HRMS). The antidiabetic potency of these compounds was evaluated by determining their activities to inhibit the α‐amylase enzyme. Compound 3d showed an IC 50 value of 1.5 × 10 −3 mg/mL, which was lower than that of the used positive control acarbose. Molecular docking calculations were also carried out, and the obtained data corroborate with the experimental findings.