article · Evidence-based Complementary and Alternative Medicine
This research evaluates the medicinal properties of a methanol extract made from the leaves of Lannea coromandelica using mouse models. The investigation focused on both central nervous system effects and blood glucose regulation. Behavioural and neurological assessments included elevated plus-maze, motor coordination, thiopental sodium-induced sleeping time, hole-board, hole-cross, and open-field tests using oral doses between 100 and 200 mg per kilogram of body weight. The leaf extract reduced exploratory and locomotor behaviours in the open-field, hole-cross, and hole-board tests. It also prolonged sleeping time induced by thiopental sodium in a dose-dependent manner. For metabolic evaluation, tests on alloxan-induced diabetic mice administered doses of 200 and 400 mg per kilogram demonstrated significant antidiabetic activity, pointing to the plant leaf extract as a potential candidate for managing blood sugar levels alongside its central nervous system actions.
Diabetes and neurological conditions require safe and effective management strategies. Evaluating medicinal plants offers a way to identify novel therapeutic compounds from natural sources. Demonstrating that Lannea coromandelica leaf extract lowers blood sugar and alters central nervous system behaviours in animal models provides scientific data that could inform future drug discovery efforts for metabolic and neuropharmacological conditions.
The findings could eventually inform pharmaceutical or nutraceutical development focused on glucose management and neuropharmacological therapies. However, the work remains at an early stage of laboratory research in rodent models. Extensive further investigation, including compound isolation, safety profiling, and clinical trials, would be required before any commercial health product could reach the market.
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The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of <i>Lannea coromandelica</i> in animal models. This study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. The experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. The hole-board test extract also demonstrated a reduced number of head dips. The findings showed that <i>L. coromandelica</i> has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research.
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DOI: 10.1155/2022/6144733
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