review · SAGE Open Medicine
Arbovirus infections that spread to the nervous system result in higher rates of illness and death. Certain factors increase an individual risk of developing severe disease, including living in or travelling to areas where these viruses are regularly found, being pregnant, older or younger age, and having a weakened immune system. At present, medical treatment for neuroinvasive arboviral diseases is primarily supportive, concentrating on addressing particular neurological complications as they arise. Because effective targeted therapies are lacking, current strategies depend heavily on preventing infection and curbing transmission between animals and humans. Developing new therapeutic interventions remains an urgent priority for managing these severe viral conditions.
When mosquito-borne and related viral infections reach the brain and nervous system, the results can be life-threatening. Understanding who is most vulnerable helps public health systems identify high-risk groups. Because doctors currently have few direct treatments to fight these neurological infections, highlighting the gaps in care is essential for guiding health policies that focus on preventative measures.
The findings point to an unmet demand for targeted therapeutics to treat neuroinvasive viral infections, which could inform drug discovery programmes targeting arboviruses. However, the abstract does not indicate a specific application pathway, technology, or commercial readiness level.
AI-generated from the published abstract. Always read the original work before citing.
Arbovirus infection with neurological manifestations leads to increased morbidity and mortality. Risk factors for disease include living and traveling in an arbovirus endemic zone, age, pregnancy, and immunosuppressed status. The management of neuroinvasive arbovirus disease is largely supportive and focuses on specific neurological complications. There is a need for therapeutics and currently, management is based on disease prevention and limiting zoonosis.
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DOI: 10.1177/20503121241229847
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