article · Scientific Reports
Abstract A sustainable and effective approach for manufacturing heterocyclic compounds was established utilizing Fe₃O₄ nanoparticles in the presence of a neodymium static magnetic field (about 9000 G). Pyrimidine, benzimidazole, quinoxaline, and benzodiazepine derivatives were swiftly synthesized at ambient temperature with excellent efficiency; no reaction transpired in the absence of a magnetic field. TEM and VSM investigations validated nanoscale dimensions (9–50 nm) and robust magnetic characteristics, facilitating efficient catalysis and straightforward recovery. The produced compounds were validated using FT-IR, 1 H NMR, 13 C NMR, and elemental analysis. The technology markedly decreased reaction time, reduced energy consumption, eliminated hazardous chemicals, and offers a sustainable pathway for synthesizing physiologically relevant heterocycles.
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DOI: 10.1038/s41598-026-51258-8
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