article · Materials Letters
An extracellular matrix (ECM)-mimetic scaffold can greatly improve the therapeutic outcomes of patients suffering with traumatic brain injuries by providing cues for regenerating neurons at the lesion site. For this, a proteosaccharide scaffold comprising of a self-assembling peptide (PuramatrixTM i.e. RADA-16 I) and chitosan was synthesised. The scaffold undergoes in situ gelation and serve as a surrogate matrix upon which neurons can proliferate as the scaffold degrades. The scaffold showed increased thermal stability, preservation of the secondary structure of Puramatrix, a microporous architecture, and slower degradation. The scaffold also promoted the proliferation of rat adrenal medulla cells with a cell viability of 163.19% over 72 h. This scaffold shows great potential for neuroregeneration.
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DOI: 10.1016/j.matlet.2024.136034
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