MICRONEEDLING ALONE VERSUS MICRONEEDLING WITH BOTULINUM TOXIN EARLY VERSUS LATE INTERVENTION IN TRAUMATIC SCARS; SPLIT SCAR COMPARATIVE STUDY .

Abstract

Introduction: Tissue repair after injury is a complex phenomenon involving intricate and coordinated mechanisms. Even though during the last decade, many studies have increased our knowledge on the different cellular players involved in this process, many gray areas remain, particularly concerning the dialogue between different cell populations acting during wound healing and scar formation. The process of wound healing after each kind of tissue defect is a complex mechanism within which a lot of different factors interact to achieve a reconstruction of the skin. The skin is composed of two main layers: the superficial layer, the epidermis, which functions as a barrier to the external environment, and the deeper layer, the dermis, which is composed of connective tissue, and provides the skin with its mechanical properties. Normal cutaneous wound healing triggered by tissue injury consists of overlapping and highly coordinated phases of hemostasis, inflammation, proliferation and remodeling.Aim of the work: The aim of this study was to compare the efficacy of microneedling alone versus its use in combination with botulinum toxin in improving post traumatic and surgical scars. Also, to compare the efficacy of the early versus late intervention in improving post traumatic and surgical scars.