review · Cancers
Micelles, which are colloidal suspensions, are attracting significant interest for their potential in both cancer diagnosis and therapy. These nanosized structures, composed of hydrophobic and hydrophilic components, have demonstrated the ability to deliver poorly water-soluble anticancer drugs, enhance drug stability, and improve drug penetration and site-specificity, thereby increasing therapeutic efficacy. They are formed simply using block copolymers or fatty acid molecules. Recent advancements include hybrid and responsive stimuli nanomicelles, which incorporate metal nanoparticles like silver, gold, or iron oxide, or combine lipids and polymers into single composites. This overview discusses these developments and their applications in cancer therapy.
Improving cancer treatment often involves overcoming challenges in drug delivery and efficacy. Micelles offer a promising strategy to deliver drugs more effectively, potentially targeting cancer cells with greater precision. This could lead to the development of more potent therapies with fewer side effects, ultimately benefiting patients.
The abstract highlights the use of micelles for improved cancer diagnosis and therapy, specifically for delivering anticancer drugs. This research is foundational, exploring advanced drug delivery systems that could lead to new pharmaceutical formulations. Potential users include pharmaceutical companies developing oncology treatments. The work appears to be early-stage research, focusing on the development and application of these delivery systems.
AI-generated from the published abstract. Always read the original work before citing.
Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.
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DOI: 10.3390/cancers10070238
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