article · Nutrients
Cisplatin is a chemotherapy drug known to cause liver damage as a side effect. Research evaluated whether a methanolic extract of date palm flesh could protect against this toxicity in male rats. Animals received either the extract, cisplatin, a combination of both, or served as controls. Assessments focused on liver biochemical parameters, oxidative stress, inflammatory markers, tissue structure, and specific signalling proteins. Administering the date extract before and alongside cisplatin significantly mitigated liver damage. It lowered serum markers of liver injury, reduced oxidative stress, and suppressed inflammatory markers. Furthermore, the extract reduced levels of cyclooxygenase-2, nuclear factor kappa B, and alpha smooth muscle actin. The hepatoprotective action of the extract appears to operate through its natural antioxidant and anti-inflammatory components, reducing the adverse effects of cisplatin treatment on liver tissue.
Chemotherapy drugs such as cisplatin often cause severe organ toxicity, limiting their clinical usefulness and harming patient health. Demonstrating that a dietary extract from date fruit can counteract drug-induced liver injury highlights potential supportive therapies. Identifying natural compounds that reduce inflammation and oxidative stress could eventually lead to safer cancer treatment protocols.
This research is at an early experimental stage using an animal model. If validated further, date flesh extracts could potentially inform the development of natural therapeutic adjuncts or nutraceuticals designed to protect the liver during chemotherapy. Pharmaceutical developers, oncologists, and nutritional supplement manufacturers would be the primary interested parties, though significant clinical testing in humans is still required before practical deployment.
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This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180-200 g) were allocated into four groups: control; date flesh (DF) group (oral 600 mg/kg MDFE for 21 days); Cis group (7.5 mg/kg i.p. at day 16); and date flesh/cisplatin (DF/Cis) group (oral 600 mg/kg MDFE for 21 days and 7.5 mg/kg i.p. at day 16). Hepatic biochemical parameters in sera, and inflammatory and oxidant/antioxidant hepatic biomarkers were estimated. Hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), and alpha smooth muscle actin (α-SMA) were assessed. Pretreatment with MDFE decreased Cis-triggered liver biochemical parameters, oxidative stress, inflammatory biomarkers, and histological damage. Moreover, MDFE treatment reduced Cis-induced hepatic NF-κB, COX-2, and α-SMA protein expression. MDFE exerted a hepatoprotective effect when used concomitantly with Cis. Its effect was mediated via its antioxidant and anti-inflammatory ingredients.
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DOI: 10.3390/nu14051025
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