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article · Medical Mycology Case Reports

Mediastinal cryptococcoma as part of disseminated cryptococcosis in HIV-negative pregnant woman with Myasthenia Gravis: Autopsy case report

Abstract

Cryptococcosis is a fungal infection commonly found in immunocompromised individuals, but it can also affect immunocompetent individuals. A pregnant woman with myasthenia gravis, HIV-negative, died after a diagnosis of tuberculosis. An autopsy revealed a mediastinal mass and organ involvement, indicating a disseminated cryptococcal infection. This case highlights the importance of maintaining a high index of suspicion for cryptococcal infection in immunosuppressed individuals, even without HIV/AIDS. Early detection is achieved by measuring serum cryptococcal antigen.

Research topics

  • Fungal Infections and Studies
  • Myasthenia Gravis and Thymoma
  • Antifungal resistance and susceptibility

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DOI: 10.1016/j.mmcr.2025.100726

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