Mapping the research landscape of minor cannabinoids: a bibliometric analysis of research trends and hotspots

Abstract

Minor cannabinoids, including cannabigerol (CBG), cannabinol (CBN), and cannabichromene (CBC), are gaining scientific attention for their distinct therapeutic potential beyond THC and CBD. Despite this growing interest, research on these compounds remains fragmented and underrepresented in the literature. This study aims to map the global research landscape of minor cannabinoids through bibliometric mapping analyses, identifying key trends, collaboration patterns, and emerging thematic areas. A structured database search of the Scopus, PubMed, and WOS databases identified 1516 eligible articles published between 1969 and 2024. An inclusive search strategy was employed to capture minor cannabinoid research as it is embedded within the broader cannabinoid literature, ensuring that studies co-analyzing major and minor cannabinoids were not overlooked. Bibliometric analysis was conducted using the Biblioshiny tool to assess publication trends, journal impact, geographic distribution, and author collaboration networks. Publication activity showed exponential growth starting in 2017, reaching a peak in 2024. The United States, Italy, and Canada led global contributions, with widespread international collaboration. Core publishing venues included Molecules, The Journal of Analytical Toxicology, the British Journal of Pharmacology, and Cannabis and Cannabinoid Research. Keyword co-occurrence analysis revealed three major thematic clusters. A sharp thematic shift has been observed since 2015, highlighting the rise of “CBG”, “CBGA” and “molecular docking”. This evolution marks a convergence of traditional pharmacology with molecular targeting and bioinformatics, signaling a transition toward computational and receptor-targeted research. Minor cannabinoid research is expanding rapidly, with strong interdisciplinary foundations and growing global collaboration. This study provides a comprehensive overview of the field’s evolution and highlights underexplored areas ripe for future investigation.