review · Reviews in Analytical Chemistry
Ashwagandha, scientifically known as Withania somnifera, is a well-known medicinal herb native to India and also found across the Middle East and regions of Africa. Highly regarded in Ayurvedic medicine, it offers diverse therapeutic benefits. It is recognised for acting as an anxiolytic, anti-inflammatory, antioxidant, adaptogen, and memory enhancer, while also demonstrating potential in managing neurodegenerative diseases. Further documented properties include antibacterial, antiviral, antitumor, aphrodisiac, and cardiovascular protective effects. Given its prominence as a valuable nutraceutical and the continuous research into bioactive phytochemicals, accurate chemical profiling is critical. Recent research focuses on qualitative and quantitative analytical techniques to identify and measure the chemical constituents in ashwagandha extracts, whilst highlighting current challenges in these analytical processes.
Ashwagandha is widely utilised as a nutraceutical for conditions ranging from anxiety to cardiovascular health. Understanding the analytical methods used to measure its active compounds is essential for standardising extracts and verifying their composition. This knowledge aids researchers and product developers seeking reliable ways to evaluate herbal ingredients and address the technical difficulties associated with natural product chemistry.
The analytical techniques reviewed are relevant to nutraceutical, dietary supplement, and pharmaceutical developers requiring reliable methods to verify and standardise ashwagandha extracts. Such testing underpins quality control and batch consistency. As the abstract focuses on evaluating analytical methodology and outlining existing technical challenges, the research operates at an early methodological stage rather than presenting a near-market commercial application.
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Abstract Ashwagandha ( Withania somnifera ) is a very popular medicinal herb originated mainly in India and found in the Middle East and parts of Africa. Ashwagandha has gained recognition as the most revered plant in Ayurvedic medicine. Studies indicated that it is used as anxiolytic, anti-inflammatory, antioxidant, adaptogen, memory enhancer, and possess an effect on neurodegenerative diseases. Additionally, it was revealed that the plant exerts antibacterial, antiviral, antitumor, aphrodisiac, and cardiovascular protection activities. Due to the biological and nutritional importance of nutraceuticals, particularly ashwagandha, and as part of the ongoing research of the natural products and its bioactive phytochemicals, this review aims to summarize the recent analytical techniques that have been reported for the determination of different chemical constituents of Withania somnifera quantitatively and qualitatively, and to highlight new challenges.
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DOI: 10.1515/revac-2022-0055
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