Lyophilized Growth Factors Foam in Chronic Ulcers

Abstract

IntroductionTreatment of chronic ulcers involves addressing the underlying cause and interventions to improve the process of healing such as autologous platelet-rich plasma. Platelet-rich plasma has been extensively studied for its potential in promoting healing of chronic ulcers as it contains a high concentration of growth factors such as platelet derived growth factor, epithelial growth factor and fibroblast growth factor. Advanced growth factor delivery systems have been developed to prolong the bio-activity of growth factors.LGF have been developed by a patented method to overcome the discrepancies of conventional platelet rich plasma.In this study, we present LGFoam as a topical agent containing Lyophilized growth factors, for use in chronic lower limb ulcers for the purpose of improving healing.MethodologyComparison of ulcer size between LGFoam topically applied to non-healing lower limb ulcers of various etiologies, as opposed to conventional dressing with a 30-day follow up period.ConclusionSeveral advanced growth factors delivery systems have been developed for topical use. However, conflicting evidence exists for their efficacy, warranting further research.In our study, there was a statistically significant decrease in ulcer size for the LGFoam group, encouraging future studies into its use in promoting wound healing in general, especially chronic non-healing ulcers as a problematic entity.