article · Journal of Nutrition and Metabolism
Lycopene is a naturally occurring carotenoid found mainly in tomatoes and products derived from them. As a dietary supplement, this phytochemical exhibits beneficial biological activities that can be utilised for wellness. Experimental evidence in laboratory and animal models indicates that lycopene mitigates metabolic dysfunctions and disorders driven by oxidative stress, including inflammation, obesity, and diabetes mellitus. In addition, it alleviates metabolic conditions affecting numerous organs and physiological networks, including the heart, liver, kidneys, lungs, eyes, bones, and the nervous system. Beyond addressing metabolic dysfunctions, lycopene provides protective effects against toxins, with existing research outlining its therapeutic safety profile, potential toxicity, and opportunities for integration into health delivery systems.
Oxidative stress contributes heavily to common metabolic illnesses, including diabetes, obesity, and broad organ damage. Clarifying the health benefits, protective mechanisms, and safety boundaries of lycopene shows how natural dietary carotenoids can help mitigate chronic conditions and inform nutritional approaches to preventative health.
The findings support applications for lycopene as a formulated dietary supplement and an intervention within health delivery systems. Prospective users include nutraceutical companies and clinical care providers addressing metabolic conditions and toxin exposure. Given that the evidence relies primarily on in vitro and in vivo studies, development remains at an early to intermediate translation stage.
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Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato-based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used as a dietary supplement. <i>In vitro</i> and <i>in vivo</i>, lycopene has been demonstrated to mitigate oxidative stress-induced metabolic dysfunctions and diseases including inflammation, obesity, and diabetes mellitus. Lycopene has been shown to alleviate metabolic diseases that affect the bone, eye, kidney, liver, lungs, heart, and nervous system. This review presents the state of the art regarding lycopene's health benefits and its potential applications in health system delivery. Furthermore, lycopene's protective effects against toxins, safety in its use, and possible toxicity are explored.
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DOI: 10.1155/2024/6252426
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