Lupus Activity in Lupus Nephritis Patients with End Stage Renal Disease Treated with Haemodialysis

Abstract

Abstract Background End-stage renal disease (ESRD) is the advanced stage of a progressive loss of kidney function. About 10% of all patients with lupus nephritis (LN) eventually progress to ESRD, which may necessitate renal replacement therapy (RRT), such as haemodialysis (HD). Assessment of lupus activity after haemodialysis initiation is crucial in improving outcomes. This issue is still under consideration by researchers. Aim of the Work The goal of this study is to analyze lupus activity in LN patients with ESRD treated with hemodialysis Patients and Methods 70 LN patients were divided into two groups: group A (35 patients) who were ESRD treated with haemodialysis, while group B (35 patients) who were chronic kidney disease (CKD) stage 3, 4. Non-renal systemic lupus erythematosus disease activity index (nrSLEDAI) score was used to assess lupus activity in both groups. Results Group A (haemodialysis group) exhibited considerably declined lupus activity compared to group B (CKD) group. With long term period maintenance on haemodialysis, there was an obvious remission in both clinical and serological parameters of lupus activity. Current doses of oral corticosteroids were less in group A than group B. Conclusion The current study's findings suggest that haemodialysis improves lupus activity clinically and serologically in what has been called burn-out phenomenon.