LSTM deep learning model for Alzheimer’s disease prediction based on cost-effective time series cognitive scores

Abstract

Alzheimer’s disease (AD) is a complex chronic neurodegenerative disease that propagates over time. Deep learning (DL) models can be used to learn time series data to extract deep temporal features and make robust decisions. The fusion of multimodal time series data has been proven to enhance model performance [1]. For instance, cognitive scores (CSs) including clinical dementia rating, and Alzheimer’s disease assessment scores have been integrated with other modalities like MRI to predict the future status of AD patients [2]. They enhanced the performance of DL models. These scores can be collected easily and in a cost-effective way in hospitals. No study in the literature has built a deep learning model to predict AD based on the cost-effective and multimodal time series data of CSs. In this study, we propose an LSTM-based DL architecture to predict AD based on multiple time series CSs. The proposed model has been optimized using a Bayesian optimizer to select the best architecture, and it has been compared with multiple classical machine learning models like random forest and others. The proposed LSTM architecture achieved better results than other models and provided stable and robust performance.