article · ChemistrySelect
Chemical analysis of a flavonoid-rich extract from Hyoscyamus albus L. gathered in the Khenchela region identified fifteen phenolic compounds, with cirsiliol emerging as the most prevalent constituent. Complementary spectroscopic analysis confirmed functional groups including phenols, carboxylic acids, and aromatics. Laboratory testing revealed that the extract possesses antioxidant capacity, performing most strongly in reducing power assessments. It also demonstrated significant antiarthritic potential, notable anti-inflammatory action through protein denaturation inhibition, and promising antidiabetic effects via yeast cell glucose uptake assays. Furthermore, the extract displayed antibacterial activity against Escherichia coli at higher tested concentrations, highlighting its potential utility as a natural source of diverse therapeutic agents.
Identifying bioactive compounds from medicinal plants offers critical starting points for treating chronic conditions such as diabetes, arthritis, and bacterial infections. By mapping the constituents and biological activities of Hyoscyamus albus, this research provides foundational evidence on natural compounds that could eventually support new therapeutic approaches for persistent inflammatory and metabolic health challenges.
This work could interest pharmaceutical and nutraceutical developers looking for plant-based leads targeting inflammatory, arthritic, or metabolic disorders. The findings demonstrate broad in vitro biological activity and identify key constituents such as cirsiliol. However, because the evidence relies strictly on preliminary laboratory and cell assays, the research remains at an early discovery stage, requiring extensive safety, mechanism, and in vivo validation before practical application.
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Abstract The current study aimed to determine the phytochemical composition of the flavonoid‐rich extract of Hyoscyamus albus L. (FEHA), collected from the Khenchela region, and to investigate its multiple bioactivities. Phytochemical profiling was explored using LC‐MS and FTIR. The antioxidant activity was assessed via five assays. Antiarthritic activity was evaluated using the albumin denaturation method. The antidiabetic effect was measured through the glucose uptake assay in yeast cells. Antibacterial activity was tested using the disk diffusion method against five bacterial strains and anti‐inflammatory potential was evaluated via inhibition of protein denaturation using the BSA technique. LC‐MS analysis identified 15 phenolic compounds, with Cirsiliol being the most abundant and FTIR spectra revealed the presence of phenols, alkanes, alkenes, alkynes, aliphatics, carboxylic acids, aromatics, and amides. Among the antioxidant tests, the reducing power method showed the highest activity. Significant antiarthritic activity was recorded, and promising antidiabetic effects were observed. The extract also exhibited notable anti‐inflammatory activity and, at higher concentrations, zone of inhibition was also observed against E . coli . These findings suggest that H. albus . could be a valuable natural source of pharmacologically active compounds with potential therapeutic applications.
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DOI: 10.1002/slct.202502921
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