Laparoscopic Roux-En-Y gastric bypass versus mini-gastric bypass for the treatment of morbid obesity and effect on glucagon-like peptide-1 level: a randomized comparative study

Abstract

Background The gold standard malabsorptive technique for patients who are morbidly obese that promotes sustained weight loss is laparoscopic Roux-en-Y gastric bypass (LRYGB). An alternative that has gained popularity is laparoscopic mini-gastric bypass (LMGB), which has the advantages of being more technically straightforward, needing less time during surgery, and having a higher food tolerance. This study compares the short-term effects of LMGB and LRYGB on weight reduction and postoperative levels of glucagon-like peptide-1 (GLP-1). Methods This prospective study included 50 morbidly obese patients who were randomly assigned to receive either LRYGB or LMGB, with 25 patients/group in the period from March 2020 to February 2021. Results Group B experienced a much shorter hospital stay and operation time than group A. There was no discernible difference between the two groups in terms of intraoperative errors or postoperative problems. Throughout the follow-up period, the patients’ weights and BMI dramatically fell in both groups, with the LMGB group seeing a much larger mean excess BMI reduction percent. Preoperative comorbidities were significantly resolved in both operations, and there was no discernible difference between the two groups. GLP-1: Following surgery, both groups exhibit a noteworthy rise in postprandial GLP-1 levels. Conclusions Compared with LRYGBP, the LMGB technique produced a greater weight loss with a similar efficiency on metabolic control.