LACTATE TO ALBUMIN RATIO AND SYSTEMIC IMMUNE INFLAMMATION INDEX AS PROGNOSTIC MARKERS OF MORTALITY IN POLYTRAUMA PATIENTS

Abstract

Polytrauma is defined as the presence of two or more injuries, at least one of which may be life-threatening, affecting multiple body regions or organ systems. It is a leading cause of mortality and disability among young adults. The condition triggers a complex immune and inflammatory response, including systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory mechanisms, which can lead to multiple organ dysfunction syndrome (MODS) and increased risk of sepsis and death. Current prognostic tools like the Injury Severity Score (ISS) and physiological markers help assess severity but remain limited in predicting outcomes, highlighting the need for more objective markers in polytrauma care.AIM OF THE WORK:The aim of study was to evaluate the role of lactate to albumin ratio and systemic immune inflammation index as prognostic markers of mortality in polytrauma patient at admission.PATIENTS AND METHODS:The required sample was collected over a period of eight months, with a minimum sample size of 70 patients who were admitted to Alexandria Main University Hospital through the Emergency Department and had a history of polytrauma according to the inclusion criteria.