Lactate/Albumin Ratio as a Predictor of Mortality in Septic Patients Presenting to Intensive Care Unit

Abstract

Abstract Background Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major healthcare problems, impacting millions of people around the world each year and killing between one in three and one in six of those it affects. Early identification and appropriate management in the initial hours after the development of sepsis improve outcomes. Aim of the Work to evaluate the prognostic value of the L/A ratio compared to lactate level for predicting sepsis-related 28 days mortality in patients admitted to ICU. Patients and Methods This Prospective observational clinical Study was performed in Ain Shams University Hospitals, Cairo, Egypt. Results Our study included 50 subjects with a median age of 63 years in non-survival group and 65 years in survival group. There was a female predominance in non-survival population (62.5%vs 37.5%), but There was a male predominance in survival population (55.9%vs 44.1%). The proportion of discharged subjects was 68% and mortality was 32%. Depending on our study results lactate, lactate albumin ratio and hemoglobin were found to be significantly (P < 0.05) in non-survivor than survivor. Also creatinine was highly significant (P < 0.001) in non-survivor than survivor. Conclusion Our study found that LA/ALB ratio on the day of admission to the ICU were potential biomarkers to mortality in patients with sepsis. LA/ALB ratio was more sensitive than lactate alone. The L/A ratio shows a positive correlation with lactate levels and APACHE-2, whereas it shows a negative correlation with albumin levels. Prospective studies should be performed to learn more about the role of the L/A ratio sepsis-related mortality.