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Labdane Diterpenoids from Leonotis ocymifolia with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell Line

2025Open accessRhodes University

Abstract

The findings from this study warrant further investigation of <i>L. ocymifolia</i> for potential triple-negative breast cancer (TNBC) therapeutic agents, including potential chemical derivatization of <i>bis</i>-spiro labdane diterpenoid (<b>1</b>) to improve selectivity to TNBC over non-cancer cells.

Research topics

  • Natural product bioactivities and synthesis
  • Phytochemistry and Biological Activities
  • Computational Drug Discovery Methods

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DOI: 10.3390/diseases13050140

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